• Chronic obstructive pulmonary disease does not impair responses to resistance training 

      Mølmen, Knut Sindre; Hammarström, Jens Konrad Daniel; Falch, Gunnar Slettaløkken; Grundtvig, Morten; Koll, Lise; Hanestadhaugen, Marita; Khan, Yusuf; Ahmad, Rafi; Malerbakken, Bente; Rødølen, Tore Jørgen; Lien, Roger; Rønnestad, Bent; Raastad, Truls; Ellefsen, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-06)
      <i>Background</i> - Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, ...
    • Increased biological relevance of transcriptome analyses in human skeletal muscle using a model-specific pipeline 

      Khan, Yusuf; Hammarström, Jens Konrad Daniel; Rønnestad, Bent; Ellefsen, Stian; Ahmad, Rafi (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-30)
      <i>Background</i> - Human skeletal muscle responds to weight-bearing exercise with significant inter-individual differences. Investigation of transcriptome responses could improve our understanding of this variation. However, this requires bioinformatic pipelines to be established and evaluated in study-specific contexts. Skeletal muscle subjected to mechanical stress, such as through resistance ...
    • Vitamin D3 supplementation does not enhance the effects of resistance training in older adults 

      Mølmen, Knut Sindre; Hammarström, Jens Konrad Daniel; Pedersen, Karianne; Lie, Anne Cecilie Lian; Steile, Ragnvald B.; Nygård, Håvard; Khan, Yusuf; Hamarsland, Håvard; Koll, Lise; Hanestadhaugen, Marita; Eriksen, Atle Lie; Grindaker, Eirik; Whist, Jon Elling; Buck, Daniel; Ahmad, Rafi; Strand, Tor Arne; Rønnestad, Bent R.; Ellefsen, Stian (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-31)
      Background: Lifestyle therapy with resistance training is a potent measure to counteract age-related loss in muscle strength and mass. Unfortunately, many individuals fail to respond in the expected manner. This phenomenon is particularly common among older adults and those with chronic diseases (e.g. chronic obstructive pulmonary disease, COPD) and may involve endocrine variables such as vitamin ...